hyaluron 4 consisting of a series of repeating disaccharide units of N-acetyl-D-glucosamine and D-glucuronic acid. It is a substance of natural origin obtained by molecular filtering.
Hyaluronic acid has a viscoelastic mechanical structure that generates an action similar to that of synovial fluid at the intra-articular level, providing lubrication and helping to maintain the structural integrity of articular cartilage. Hyaluron has proven to be an extremely useful therapeutic agent for managing joint functions as well as activating articular cartilage repair processes in a variety of animal species, especially horses and canines.
hyaluron is a colorless, crystalline, viscous solution resulting from a process of high purification and filtration of Hyaluronic acid.
Hyaluronic acid is a natural substance, present in the animal body both in connective tissue, joints as well as in skin and vitreous humor.
The mechanism of action in healing degenerative joint disease seems to be direct action on
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hyaluron is indicated as an intra-articular treatment in acute or chronic synovitis related to non-infectious osteoarthritis.
Intravenous hyaluron has been successfully used as a preventive in competitive horses with excessive physical activity, for the treatment of joint dysfunction as a consequence of synovitis associated with osteoarthritis.
IV administration has the advantage of acting systemically and rapidly.
In damaged cartilage, the administration of hyaluron produces anti-inflammatory action, can inhibit overgrowth and prevent cartilage destruction, as well as the formation of adhesions. In most cases, after treatment with hyaluron, a rapid decrease in pain and greater joint mobility is observed
Do not inject hyaluron into infected joints.
Strict asepsis is recommended at the intra-articular injection site, which is performed through healthy skin and by a veterinarian.
Do not administer intramuscularly. hyaluron 4
Do not use in animals intended for human consumption.
Any excess synovial fluid (intra-articular effusion) must be removed aseptically before hyaluron injection.
In isolated cases, as a secondary effect, a slight inflammation may appear after the IA application of hyaluron within 24 and 48 hours after its application. It is a process resulting from the friction of the needle within the joint that is quickly reversed. If it persists, the possibility of infection and appropriate antibiotic therapy should be considered.
ADMINISTRATION AND DOSAGE
The recommended dose of intraarticular hyaluron in horses is 2 mL (20 mg) per joint, and up to 4 mL (40 mg) can be applied in large joints.
In acute cases, one treatment is generally sufficient, and the application can be repeated after 7 or 14 days. If the joint presents joint effusion, the excess synovial fluid must be removed prior to the injection of hyaluron.
It is recommended to keep the horse on sports rest for 2 days after the IA injection or to work it in a very limited way.
If necessary, hyaluron can be associated with corticosteroids for intra-articular use in the same injection.
By IV route, the recommended dose of hyaluron is 4 mL (40 mg) in a single weekly injection. In chronic or severe cases, it is convenient to apply this dose for 4 or 5 weeks, or for as long as the veterinarian deems appropriate.
hyaluron 2 in a 2 mL vial containing 20 mg of sodium hyaluronidate
hyaluron 4 in a 4 mL vial containing 40 mg of sodium hyaluronidate