solu medrol 500mg
solu medrol 500mg
solu medrol 500mg Methylprednisolone is a synthetic drug from the group of glucocorticoid hormones for parenteral, oral, rectal and topical use. In terms of chemical structure, it is a modified derivative of prednisolone. Methylprednisolone was first synthesized in the
active substance: methylprednisolone;
1 bottle contains 500 mg of methylprednisolone in the form of methylprednisolone sodium succinate;
excipients: for a dosage of 500 mg – sodium dihydrogen phosphate monohydrate, sodium phosphate anhydrous;
solvent for dosing 500 mg: benzyl alcohol (9 mg / ml), water for injection.
Powder and solvent for preparation of solution for injection.
Basic physical and chemical properties:
powder: white to off-white lyophilisate;
solvent for dispensing 500 mg: clear, colorless liquid with a slight odor of benzyl alcohol.
Systemic corticosteroids. ATX code Н02A В04.
This drug is an injectable form of methylprednisolone (synthetic GCS) for intramuscular and intravenous administration. This highly concentrated solution is suitable, in particular, for the treatment of pathological conditions in which an effective and rapid action of the hormone is required. Methylprednisolone has a strong anti-inflammatory, immunosuppressive and anti-allergic effect.
Glucocorticoids penetrate the cell membrane by diffusion and form complexes with specific receptors in the cytoplasm. Further, these complexes enter the cell nucleus, bind to DNA (chromatin) and stimulate the transcription of mRNA and further synthesis of proteins by various enzymes, which, in turn, are responsible for the numerous effects of glucocorticoids after systemic use. solu medrol 500mg
Glucocorticoids not only show significant effects on inflammatory and immune processes, but also affect the metabolism of carbohydrates, proteins and fats. They also act on the cardiovascular system, skeletal muscle, and the central nervous system.
Influence on inflammatory and immune processes.
The anti-inflammatory, immunosuppressive and anti-allergic properties of glucocorticoids are used for most therapeutic indications. The presence of these properties leads to the following results:
- a decrease in the number of immunoactive cells around the focus of inflammation;
- decrease in vasodilation;
- stabilization of lysosomal membranes;
- inhibition of phagocytosis;solu medrol 500mg
- reduction of the formation of prostaglandins and related substances.
A 4 mg dose of methylprednisolone has the same glucocorticosteroid (anti-inflammatory) effect as hydrocortisone 20 mg. Methylprednisolone demonstrates only a minimal mineralocorticoid effect (200 mg of methylprednisolone corresponds to 1 mg of deoxycorticoste
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The diagnosis and the choice of the treatment method is carried out only by your attending physician !