Phenylarthrite shows a real potentiation of the anti-inflammatory effects of isolated drugs. Thanks to phenylbutazone, there is a strong inhibition of the action of the enzyme cyclooxygenase (COX-2) in the production of mediators of inflammation. Dexamethasone, on the other hand, inhibits the expression of COX-2, inhibiting the transcription of the relevant gene and, therefore, reduces …
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